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Wet Granulation Scale-Up: The Binder Addition DilemmaWet granulation remains the most classic, widely used, and scale-up-challenging process in solid dosage form development.Key sensitive parameters include binder concentration, amount, addition method and time, plus impeller and chopper speed and d
Wet granulation combines powders with liquid binders (e.g., water/ethanol) to form granules, improving flowability and uniformity for tablet compression. It uses a high-shear mixer with a pot, agitator, and chopper to mix and cut the material. Key controls include binder amount (affects moisture), agitator speed (shear force), and chopper speed (particle size).
2025-12-09
Innov Machinery
Hunan Innov Equipment Co., Ltd., established in 2014, specializes in the research and development, production, and global distribution of machinery and equipment.
